idiopathic pulmonary fibrosis

lung

CCN2

mRNA

up regulation

homo sapiens

Data compilation; Statistical analysis etc.

NA

NA

Transcriptome of Cultured Lung Fibroblasts in Idiopathic Pulmonary Fibrosis: Meta-Analysis of Publically Available Microarray Datasets Reveals Repression of Inflammation and Immunity Pathways

2016

"CTGF, a member of the CCN protein family, is a highly potent extracellular matrix-associated mitogen. In vitro, CTGF induces collagen-1 expression in lung fibroblasts [20]. In vivo, overexpression of CTGF in fibroblasts drives fibrogenesis in multiple organs including the lung [21]. CTGF is overexpressed in IPF, with expression localized to alveolar epithelial cells and fibroblasts [22]. Consistent for a role of CTGF in IPF, a recent open-label uncontrolled study suggested that a monoclonal antibody targeting CTGF, FG-3019, may be beneficial in a subset of IPF patients in terms of lung function decline and imaging-assessed fibrotic changes [23]."